Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network.
J Struct Funct Genomics
; 15(4): 209-14, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-24989974
ABSTRACT
High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30% sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein-protein interactions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas do Citoesqueleto
/
Proteínas de Neoplasias
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article