Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors.

Rothwell, Patrick E; Fuccillo, Marc V; Maxeiner, Stephan; Hayton, Scott J; Gokce, Ozgun; Lim, Byung Kook; Fowler, Stephen C; Malenka, Robert C; Südhof, Thomas C

Rothwell, Patrick E; Fuccillo, Marc V; Maxeiner, Stephan; Hayton, Scott J; Gokce, Ozgun; Lim, Byung Kook; Fowler, Stephen C; Malenka, Robert C; Südhof, Thomas C.

Afiliação

Rothwell PE; Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305, USA; Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, CA 94305, USA.
Fuccillo MV; Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305, USA; Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, CA 94305, USA.
Maxeiner S; Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305, USA.
Hayton SJ; Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, CA 94305, USA.
Gokce O; Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305, USA.
Lim BK; Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, CA 94305, USA.
Fowler SC; Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA.
Malenka RC; Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, CA 94305, USA. Electronic address: malenka@stanford.edu.
Südhof TC; Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA. Electronic address: tcs1@stanford.edu.

Cell ; 158(1): 198-212, 2014 Jul 03.

Article em En | MEDLINE | ID: mdl-24995986

Assuntos

Transtorno Autístico/genética; Transtorno Autístico/fisiopatologia; Moléculas de Adesão Celular Neuronais/genética; Proteínas de Membrana/genética; Proteínas do Tecido Nervoso/genética; Animais; Transtorno Autístico/metabolismo; Gânglios da Base/metabolismo; Gânglios da Base/fisiopatologia; Moléculas de Adesão Celular Neuronais/metabolismo; Humanos; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Knockout; Mutação; Proteínas do Tecido Nervoso/metabolismo; Núcleo Accumbens/metabolismo; Teste de Desempenho do Rota-Rod

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Autístico / Moléculas de Adesão Celular Neuronais / Proteínas de Membrana / Proteínas do Tecido Nervoso Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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