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Plasmodium falciparum transmission stages accumulate in the human bone marrow.
Joice, Regina; Nilsson, Sandra K; Montgomery, Jacqui; Dankwa, Selasi; Egan, Elizabeth; Morahan, Belinda; Seydel, Karl B; Bertuccini, Lucia; Alano, Pietro; Williamson, Kim C; Duraisingh, Manoj T; Taylor, Terrie E; Milner, Danny A; Marti, Matthias.
Afiliação
  • Joice R; Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
  • Nilsson SK; Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
  • Montgomery J; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, P. O. Box 30096, Chichiri, Blantyre 3, Malawi. Liverpool School of Tropical Medicine, University of Liverpool, Liverpool L3 5QA, UK.
  • Dankwa S; Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
  • Egan E; Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
  • Morahan B; Department of Biology, Loyola University, 1032 West Sheridan Road, Chicago, IL 60660, USA.
  • Seydel KB; Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre 3, Malawi. College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA.
  • Bertuccini L; Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena n. 299, 00191 Rome, Italy.
  • Alano P; Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena n. 299, 00191 Rome, Italy.
  • Williamson KC; Department of Biology, Loyola University, 1032 West Sheridan Road, Chicago, IL 60660, USA.
  • Duraisingh MT; Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
  • Taylor TE; Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre 3, Malawi. College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA.
  • Milner DA; Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre 3, Malawi. Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, M
  • Marti M; Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. mmarti@hsph.harvard.edu.
Sci Transl Med ; 6(244): 244re5, 2014 Jul 09.
Article em En | MEDLINE | ID: mdl-25009232
ABSTRACT
Transmission of Plasmodium falciparum malaria parasites requires formation and development of gametocytes, yet all but the most mature of these sexual parasite forms are absent from the blood circulation. We performed a systematic organ survey in pediatric cases of fatal malaria to characterize the spatial dynamics of gametocyte development in the human host. Histological studies revealed a niche in the extravascular space of the human bone marrow where gametocytes formed in erythroid precursor cells and underwent development before reentering the circulation. Accumulation of gametocytes in the hematopoietic system of human bone marrow did not rely on cytoadherence to the vasculature as does sequestration of asexual-stage parasites. This suggests a different mechanism for the sequestration of gametocytes that could potentially be exploited to block malaria transmission.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Medula Óssea / Malária Falciparum / Estágios do Ciclo de Vida Limite: Child / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Medula Óssea / Malária Falciparum / Estágios do Ciclo de Vida Limite: Child / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article