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Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.
Ghosh, Rajarshi; Wang, Likun; Wang, Eric S; Perera, B Gayani K; Igbaria, Aeid; Morita, Shuhei; Prado, Kris; Thamsen, Maike; Caswell, Deborah; Macias, Hector; Weiberth, Kurt F; Gliedt, Micah J; Alavi, Marcel V; Hari, Sanjay B; Mitra, Arinjay K; Bhhatarai, Barun; Schürer, Stephan C; Snapp, Erik L; Gould, Douglas B; German, Michael S; Backes, Bradley J; Maly, Dustin J; Oakes, Scott A; Papa, Feroz R.
Afiliação
  • Ghosh R; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center,
  • Wang L; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for
  • Wang ES; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Perera BG; Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
  • Igbaria A; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for
  • Morita S; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for
  • Prado K; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for
  • Thamsen M; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for
  • Caswell D; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Macias H; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Weiberth KF; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for
  • Gliedt MJ; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Alavi MV; Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Hari SB; Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
  • Mitra AK; Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
  • Bhhatarai B; Department of Molecular and Cellular Pharmacology,, Miller School of Medicine, University of Miami, FL 33136, USA.
  • Schürer SC; Center for Computational Science, Miller School of Medicine, University of Miami, FL 33136, USA; Department of Molecular and Cellular Pharmacology,, Miller School of Medicine, University of Miami, FL 33136, USA.
  • Snapp EL; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Gould DB; Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
  • German MS; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Backes BJ; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Maly DJ; Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
  • Oakes SA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: scott.oakes@ucsf.edu.
  • Papa FR; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for
Cell ; 158(3): 534-48, 2014 Jul 31.
Article em En | MEDLINE | ID: mdl-25018104
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Endorribonucleases / Estresse do Retículo Endoplasmático Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Endorribonucleases / Estresse do Retículo Endoplasmático Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article