Do NIA-AA criteria distinguish Alzheimer's disease from frontotemporal dementia?
Alzheimers Dement
; 11(2): 207-15, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25022535
ABSTRACT
BACKGROUND:
Clinical criteria are important for improving diagnostic accuracy and ensuring comparability of patient cohorts in research studies.OBJECTIVE:
The aim was to assess the National Institute on Aging and Alzheimer's Association (NIA-AA) criteria for Alzheimer's disease (AD) dementia in AD and frontotemporal lobar degeneration (FTLD).METHODS:
Two hundred twelve consecutive patients with pathologically confirmed AD or FTLD who were clinically assessed in a specialist cognitive unit were identified. Fifty-five patients were excluded predominantly because of insufficient clinical information. Anonymized clinical data were rated against the NIA-AA criteria by raters who were blinded to clinical and pathologic diagnosis.RESULTS:
The NIA-AA AD dementia criteria had a sensitivity of 65.6% for probable and 79.5% for possible AD and a specificity of 95.2% and 94.0% for probable and possible, respectively.CONCLUSION:
In patients with FTLD and predominantly early-onset AD, the NIA-AA AD dementia criteria have high specificity but lower sensitivity. The high specificity is due to the broad exclusion criteria.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Indicadores Básicos de Saúde
/
Demência Frontotemporal
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Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article