Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.

Erlendsson, Simon; Rathje, Mette; Heidarsson, Pétur O; Poulsen, Flemming M; Madsen, Kenneth L; Teilum, Kaare; Gether, Ulrik

Erlendsson, Simon; Rathje, Mette; Heidarsson, Pétur O; Poulsen, Flemming M; Madsen, Kenneth L; Teilum, Kaare; Gether, Ulrik.

Afiliação

Erlendsson S; From the Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute 18.6, University of Copenhagen, 2200 Copenhagen N and the Structural Biology and NMR
Rathje M; From the Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute 18.6, University of Copenhagen, 2200 Copenhagen N and.
Heidarsson PO; the Structural Biology and NMR Laboratory, Department of Biology, Faculty of Science, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.
Poulsen FM; the Structural Biology and NMR Laboratory, Department of Biology, Faculty of Science, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.
Madsen KL; From the Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute 18.6, University of Copenhagen, 2200 Copenhagen N and.
Teilum K; the Structural Biology and NMR Laboratory, Department of Biology, Faculty of Science, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark kaare.teilum@bio.ku.dk.
Gether U; From the Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute 18.6, University of Copenhagen, 2200 Copenhagen N and gether@sund.ku.dk.

J Biol Chem ; 289(36): 25327-40, 2014 Sep 05.

Article em En | MEDLINE | ID: mdl-25023278

Assuntos

Proteínas de Transporte/química; Simulação de Acoplamento Molecular/métodos; Proteínas Nucleares/química; Domínios PDZ; Sequência de Aminoácidos; Sítios de Ligação/genética; Ligação Competitiva; Proteínas de Transporte/genética; Proteínas de Transporte/metabolismo; Polarização de Fluorescência; Humanos; Ligantes; Espectroscopia de Ressonância Magnética; Mutação; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Peptídeos/química; Peptídeos/metabolismo; Ligação Proteica; Proteína Quinase C-alfa/química; Proteína Quinase C-alfa/genética; Proteína Quinase C-alfa/metabolismo

Palavras-chave

Nuclear Magnetic Resonance (NMR); PDZ Domains; Protein Structure; Protein-Protein Interaction; Scaffold Protein; Signal Transduction; Trafficking

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Proteínas de Transporte / Domínios PDZ / Simulação de Acoplamento Molecular Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google