Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders.
J Neuroimmunol
; 274(1-2): 155-60, 2014 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-25027061
ABSTRACT
Anti-aquaporin 4 (AQP4) antibodies (Abs) are essential in neuromyelitis optica spectrum disorders (NMOSD), but the relationship between CNS demyelinating disorders (CNSDD) and other neural Abs remains unclear. Here we screened anti-neural Abs in the sera of 70 Japanese CNSDD patients. While two had only demyelinating events among three anti-N-methyl-d-aspartate receptor (NMDAR) Ab-positive subjects, the other subject who also had anti-AQP4 Abs experienced episodes of anti-NMDAR encephalitis and of NMOSD. Major lesions in the three anti-contactin-associated protein 2 Ab-positive subjects were infratentorial, including one co-carrying anti-AQP4 Abs. Thus, autoantibodies can be clinically silent, but multiple autoantibodies may participate in the pathogenesis.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Autoantígenos
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Neuromielite Óptica
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Povo Asiático
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Aquaporina 4
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Proteínas de Membrana
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Esclerose Múltipla
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Proteínas do Tecido Nervoso
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article