[Association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphism with male infertility].
Zhonghua Nan Ke Xue
; 20(6): 518-22, 2014 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-25029857
ABSTRACT
OBJECTIVE:
To explore the association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphism with semen quality and the risk of male infertility.METHODS:
This case-control study included 620 idiopathic infertile patients and 385 normal fertile controls. We determined their genotypes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and analyzed their semen quality by computer-aided semen analysis (CASA).RESULTS:
The individuals with OGG1 326 Cys/Cys showed significantly lower sperm motility and concentration ([52.1 +/- 26.7]% and (3.75 +/- 0.91) x 10(6)/ml, ln transformed value) than the Ser/Ser carriers ([59.0 +/- 21.8] % and (4.12 +/- 0.88) x 10(6)/ml, ln transformed value) (P < 0.05). The risk of male infertility increased 69% in the OGG1 326Cys allele carriers as compared with the Ser carriers (OR = 1.69, 95% CI 1.24 -2.31).CONCLUSION:
OGG1 326 Ser/Cys polymorphism might contribute to the risk of male infertility in the southern Chinese population.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Nucleotídeo Único
/
DNA Glicosilases
/
Infertilidade Masculina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article