Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review.
Age Ageing
; 43(5): 604-15, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-25038833
ABSTRACT
OBJECTIVES:
to determine the effect of drugs with anti-cholinergic properties on relevant health outcomes.DESIGN:
electronic published and unpublished literature/trial registries were systematically reviewed. Studies evaluating medications with anti-cholinergic activity on cognitive function, delirium, physical function or mortality were eligible.RESULTS:
forty-six studies including 60,944 participants were included. Seventy-seven percent of included studies evaluating cognitive function (n = 33) reported a significant decline in cognitive ability with increasing anti-cholinergic load (P < 0.05). Four of five included studies reported no association with delirium and increasing anti-cholinergic drug load (P > 0.05). Five of the eight included studies reported a decline in physical function in users of anti-cholinergics (P < 0.05). Three of nine studies evaluating mortality reported that the use of drugs with anti-cholinergic properties was associated with a trend towards increased mortality, but this was not statistically significant. The methodological quality of the evidence-base ranged from poor to very good.CONCLUSION:
medicines with anti-cholinergic properties have a significant adverse effect on cognitive and physical function, but limited evidence exists for delirium or mortality outcomes.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nível de Saúde
/
Cognição
/
Transtornos Cognitivos
/
Antagonistas Colinérgicos
/
Delírio
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article