Genetic association signal near NTN4 in Tourette syndrome.
Ann Neurol
; 76(2): 310-5, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-25042818
ABSTRACT
Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10(-4) ) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10(-7) ). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Tourette
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Estudo de Associação Genômica Ampla
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Fatores de Crescimento Neural
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Adult
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article