Engineering enzyme-cleavable hybrid click capsules with a pH-sheddable coating for intracellular degradation.
Small
; 10(20): 4080-6, 2014 Oct 29.
Article
em En
| MEDLINE
| ID: mdl-25044500
ABSTRACT
The engineering of layer-by-layer (LbL) hybrid click capsules that are responsive to biological stimuli is reported. The capsules comprise a pH-sheddable, non cross-linked outer coating that protects enzyme-cleavable inner layers. Upon cellular uptake, the outer coating is released and the capsules are enzymatically degraded. In vitro cell degradation results in rapid capsule degradation (10 min) upon cellular internalization.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cápsulas
/
Enzimas
/
Concentração de Íons de Hidrogênio
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article