Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.

Ehara, Takeru; Irie, Osamu; Kosaka, Takatoshi; Kanazawa, Takanori; Breitenstein, Werner; Grosche, Philipp; Ostermann, Nils; Suzuki, Masaki; Kawakami, Shimpei; Konishi, Kazuhide; Hitomi, Yuko; Toyao, Atsushi; Gunji, Hiroki; Cumin, Frederic; Schiering, Nikolaus; Wagner, Trixie; Rigel, Dean F; Webb, Randy L; Maibaum, Jürgen; Yokokawa, Fumiaki

Ehara, Takeru; Irie, Osamu; Kosaka, Takatoshi; Kanazawa, Takanori; Breitenstein, Werner; Grosche, Philipp; Ostermann, Nils; Suzuki, Masaki; Kawakami, Shimpei; Konishi, Kazuhide; Hitomi, Yuko; Toyao, Atsushi; Gunji, Hiroki; Cumin, Frederic; Schiering, Nikolaus; Wagner, Trixie; Rigel, Dean F; Webb, Randy L; Maibaum, Jürgen; Yokokawa, Fumiaki.

Afiliação

Ehara T; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
Irie O; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
Kosaka T; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
Kanazawa T; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
Breitenstein W; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
Grosche P; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
Ostermann N; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
Suzuki M; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
Kawakami S; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
Konishi K; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
Hitomi Y; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
Toyao A; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
Gunji H; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
Cumin F; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
Schiering N; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
Wagner T; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
Rigel DF; Novartis Pharmaceuticals Corp., Institutes for BioMedical Research , East Hanover, New Jersey 07936, United States.
Webb RL; Novartis Pharmaceuticals Corp., Institutes for BioMedical Research , East Hanover, New Jersey 07936, United States.
Maibaum J; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
Yokokawa F; Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.