An enzymatic approach to bifunctional chelating agents.
Org Biomol Chem
; 12(35): 6915-21, 2014 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-25060174
ABSTRACT
Bifunctional chelating agents (BFCAs) combine the complexing properties of a multidentate ligand with the presence of a free reactive functional group, mainly devoted to conjugation purposes. Indeed, products obtained by conjugation of a BFCA to a biomolecule and coordination of a suitable metal ion are widely applied in medicine nowadays as diagnostic and therapeutic agents. BFCAs are generally prepared through multi-step syntheses and with extensive application of protection-deprotection strategies, due to the large number of functional groups involved. Hydrolytic enzymes, with their unique chemoselectivity, provided the best results in the preparation of three different BFCAs based on very useful and well known ligand platforms.
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Base de dados:
MEDLINE
Assunto principal:
Quelantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article