Lipoxygenase inhibitors suppress formation of tumor necrosis factor in vitro and in vivo.
Lymphokine Res
; 8(3): 245-50, 1989.
Article
em En
| MEDLINE
| ID: mdl-2506396
ABSTRACT
The LPS induced synthesis of tumor necrosis factor in macrophage cultures, as determined in a fibroblast cytolysis assay was found to be effectively blocked by inhibitors of lipoxygenases. Likewise, the presence of tumor necrosis factor in serum of D-galactosamine sensitized mice after challenge with endotoxin was suppressed by the lipoxygenase inhibitors. Indomethacin, a blocker of cycclooxygenase was neither in vivo nor in vitro effective in the prevention of the endotoxin-induced synthesis of TNF. From LPS-treated macrophages we were able to isolate 13-hydroxylinoleic acid, a lipoxygenase product, which is significantly increased after LPS treatment of the cells, covalently bound to cellular constituents and may, therefore, be possibly involved in the formation of TNF.
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Base de dados:
MEDLINE
Assunto principal:
Fator de Necrose Tumoral alfa
/
Inibidores de Lipoxigenase
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article