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Longitudinal profiles of adaptive behavior in fragile X syndrome.
Klaiman, Cheryl; Quintin, Eve-Marie; Jo, Booil; Lightbody, Amy A; Hazlett, Heather Cody; Piven, Joseph; Hall, Scott S; Chromik, Lindsay C; Reiss, Allan L.
Afiliação
  • Klaiman C; Marcus Autism Center, Children's Healthcare of Atlanta, Atlanta, Georgia;Emory University, School of Medicine, Atlanta, Georgia; Cheryl.klaiman@emory.edu.
  • Quintin EM; Georgia Institute of Technology, School of Psychology, Atlanta, Georgia;
  • Jo B; Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Brain Sciences, Stanford University, Palo Alto, California;
  • Lightbody AA; Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Brain Sciences, Stanford University, Palo Alto, California;
  • Hazlett HC; Carolina Institute for Developmental Disabilities, andDepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  • Piven J; Carolina Institute for Developmental Disabilities, andDepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  • Hall SS; Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Brain Sciences, Stanford University, Palo Alto, California;
  • Reiss AL; Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Brain Sciences, Stanford University, Palo Alto, California;Departments of Radiology, andPediatrics, Stanford University, Palo Alto, California; and.
Pediatrics ; 134(2): 315-24, 2014 Aug.
Article em En | MEDLINE | ID: mdl-25070318
OBJECTIVE: To examine longitudinally the adaptive behavior patterns in fragile X syndrome. METHOD: Caregivers of 275 children and adolescents with fragile X syndrome and 225 typically developing children and adolescents (2-18 years) were interviewed with the Vineland Adaptive Behavior Scales every 2 to 4 years as part of a prospective longitudinal study. RESULTS: Standard scores of adaptive behavior in people with fragile X syndrome are marked by a significant decline over time in all domains for males and in communication for females. Socialization skills are a relative strength as compared with the other domains for males with fragile X syndrome. Females with fragile X syndrome did not show a discernible pattern of developmental strengths and weaknesses. CONCLUSIONS: This is the first large-scale longitudinal study to show that the acquisition of adaptive behavior slows as individuals with fragile X syndrome age. It is imperative to ensure that assessments of adaptive behavior skills are part of intervention programs focusing on childhood and adolescence in this condition.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do Cromossomo X Frágil Tipo de estudo: Observational_studies / Qualitative_research / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do Cromossomo X Frágil Tipo de estudo: Observational_studies / Qualitative_research / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article