Short-T2 imaging for quantifying concentration of sodium (23 Na) of bi-exponential T2 relaxation.
Magn Reson Med
; 74(1): 162-174, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25078966
ABSTRACT
PURPOSE:
This work intends to demonstrate a new method for quantifying concentration of sodium (23 Na) of bi-exponential T2 relaxation in patients on MRI scanners at 3.0 Tesla. THEORY ANDMETHODS:
Two single-quantum (SQ) sodium images acquired at very-short and short echo times (TE = 0.5 and 5.0 ms) are subtracted to produce an image of the short-T2 component of the bi-exponential (or bound) sodium. An integrated calibration on the SQ and short-T2 images quantifies both total and bound sodium concentrations. Numerical models were used to evaluate signal response of the proposed method to the short-T2 components. MRI scans on agar phantoms and brain tumor patients were performed to assess accuracy and performance of the proposed method, in comparison with a conventional method of triple-quantum filtering.RESULTS:
A good linear relation (R2 = 0.98) was attained between the short-T2 image intensity and concentration of bound sodium. A reduced total scan time of 22 min was achieved under the SAR restriction for human studies in quantifying both total and bound sodium concentrations.CONCLUSION:
The proposed method is feasible for quantifying bound sodium concentration in routine clinical settings at 3.0 Tesla. Magn Reson Med 74162-174, 2015. © 2014 Wiley Periodicals, Inc.
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MEDLINE
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article