Construction of functional neuronal circuitry in the olfactory bulb.
Semin Cell Dev Biol
; 35: 180-8, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25084319
ABSTRACT
Recent studies using molecular genetics, electrophysiology, in vivo imaging, and behavioral analyses have elucidated detailed connectivity and function of the mammalian olfactory circuits. The olfactory bulb is the first relay station of olfactory perception in the brain, but it is more than a simple relay olfactory information is dynamically tuned by local olfactory bulb circuits and converted to spatiotemporal neural code for higher-order information processing. Because the olfactory bulb processes â¼1000 discrete input channels from different odorant receptors, it serves as a good model to study neuronal wiring specificity, from both functional and developmental aspects. This review summarizes our current understanding of the olfactory bulb circuitry from functional standpoint and discusses important future studies with particular focus on its development and plasticity.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
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Modelos Neurológicos
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Rede Nervosa
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Neurônios
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article