Synthesis and inhibitory activity on hepatitis C virus RNA replication of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)aniline analogs.
Bioorg Med Chem Lett
; 24(17): 4276-80, 2014 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-25086684
ABSTRACT
Using our recently developed assay system for full-genome-length hepatitis C virus (HCV) RNA replication in human hepatoma-derived Li23 cells (ORL8), we identified 4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)aniline analog 1a as a novel HCV inhibitor. Structural modifications of 1a provided a series of sulfonamides 7 with much more potent HCV RNA replication-inhibitory activity than ribavirin. Compound 7a showed an additive anti-HCV effect in combination with standard anti-HCV therapy (IFN-α plus ribavirin). Since 7a generated reactive oxygen species (ROS) in the ORL8 system and its anti-HCV activity was blocked by vitamin E, its anti-HCV activity may be mediated at least in part by ROS.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Sulfonamidas
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RNA Viral
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Hepacivirus
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article