New α-glucosidase inhibitors with p-terphenyl skeleton from the mushroom Hydnellum concrescens.
Fitoterapia
; 98: 149-55, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25088970
ABSTRACT
The purpose of this study is to elucidate the bioactive components responsible for the the α-glucosidase inhibitory activity detected in the EtOAc extract of the mushroom Hydnellum concrescens. Two new p-terphenyl derivatives, concrescenins A (1) and B (2), in along with six known compounds thelephantins L (3), I (4), J (5), K (6), dihydroauran-tiacin dibenzoate (7), and curtisian A (8) were isolated from the fruiting bodies of H. concrescens. Their chemical structures were elucidated by NMR experiments. Compounds 1-4 and 6-8 showed the inhibitory activity against α-glucosidase with the IC50 of 0.99, 3.11, 4.53, 18.77, 2.98, 5.16, and 8.34 µM, respectively. Kinetic analysis of α-glucosidase indicated that compounds 1 and 2 inhibited the activity of α-glucosidase in a noncompetitive fashion with a Ki value of 0.02 and 0.21 µM, respectively. In antioxidant evaluation, compounds 1 and 4 showed weak DPPH scavenging activity (EC50=82.50 and 161.75 µM) and weak reducing ability (EC50=193.57 and 152.94 µM). The current research supports the potential use of mushroom-derived p-terphenyl derivatives for the treatment of diabetes.
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Base de dados:
MEDLINE
Assunto principal:
Compostos de Terfenil
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Basidiomycota
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Agaricales
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Inibidores de Glicosídeo Hidrolases
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article