[Optimization of ultrasonic extraction conditions of safflower yellow from Carthamus tinctorius by response surface methodology].

ABSTRACT

OBJECTIVE: To investigate the optimization of extraction conditions of safflower yellow from Cartbamus tirwtorius by response surface methodology. METHODS: Experimental factors and levels were selected by one-factor test, and then according to the central composite experimental design principle, response surface'-methodology with three factors and three levels was used to establish a mathematical model to obtain the optimal extraction conditions with hydroxysafflower yellow A being the target and its extraction yield as response value. RESULTS: The optimal extraction conditions of safflower yellow were as follows extraction temperature was 55 t, ratio of water to raw material was 161 and extraction time was 39 mm for three times. CONCLUSION: Under these conditions, the extraction yield of safflower yellow is 1.798%, and the relative error between the predicted value with actual value is 2.758%. The optimized method can provide reference for the efficient extraction of safflower yellow from Carthomos tinctorius