Synthesis of functionalized arylaziridines as potential antimicrobial agents.
Molecules
; 19(8): 11505-19, 2014 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-25093988
ABSTRACT
By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aziridinas
/
Anti-Infecciosos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article