MTLRP genetic polymorphism (214C>A) was associated with Type 2 diabetes in Caucasian population: a meta-analysis.
Lipids Health Dis
; 13: 124, 2014 Aug 05.
Article
em En
| MEDLINE
| ID: mdl-25095788
ABSTRACT
BACKGROUND:
Previous studies reported the relation between MTLRP genetic polymorphism and type 2 diabetes, however, the conclusion were conflicting. In the present study, we performed a meta-analysis to reveal this association.METHODS:
Literature retrieval, selection and assessment, data extraction, and meta-analyses were performed according to the RevMan 5.0 guidelines. In the meta-analysis, we utilized random-effect model or fixed-effect model to pool the Odds ratio (OR) according to the test of heterogeneity.RESULTS:
A total of nine case-control studies included 4460 type 2 diabetes patients and 4114 healthy control subjects were analyzed. We did not found association between the MTLRP polymorphism and type 2 diabetes risk in the overall population (CC vs CA + AA OR = 1.02; 95% CI 0.89-1.17, P = 0.77; A vs C OR = 1.02; 95% CI 0.84-0.96, P = 0.62). However, in subgroup analyses stratified by ethnicity, we found significant association of MTLRP polymorphism with type 2 diabetes in Caucasians (CC vs CA + AA OR = 1.27; 95% CI 1.02-1.57, P = 0.03; A vs C OR = 0.74, 95% CI 0.60-0.91, P = 0.005).CONCLUSION:
The MTLRP polymorphism was associated with type 2 diabetes in Caucasians.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
/
Grelina
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article