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A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity.
Choi, Sun-Sil; Kim, Eun Sun; Koh, Minseob; Lee, Soo-Jin; Lim, Donghyun; Yang, Yong Ryoul; Jang, Hyun-Jun; Seo, Kyung-Ah; Min, Sang-Hyun; Lee, In Hee; Park, Seung Bum; Suh, Pann-Ghill; Choi, Jang Hyun.
Afiliação
  • Choi SS; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan 689-798, Korea.
  • Kim ES; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan 689-798, Korea.
  • Koh M; Department of Chemistry, Seoul National University, Seoul 151-747, Korea.
  • Lee SJ; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan 689-798, Korea.
  • Lim D; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Dong-gu, Daegu 701-310, Korea.
  • Yang YR; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan 689-798, Korea.
  • Jang HJ; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan 689-798, Korea.
  • Seo KA; Department of Biophysics and Chemical Biology/Bio-MAX Institute, Seoul National University, Seoul 151-747, Korea, and.
  • Min SH; Department of Biophysics and Chemical Biology/Bio-MAX Institute, Seoul National University, Seoul 151-747, Korea, and.
  • Lee IH; Department of Medical Chemistry, Hyundai Pharm Co., Ltd., Suwon, Gyonggi 443-270, Korea.
  • Park SB; Department of Chemistry, Seoul National University, Seoul 151-747, Korea,; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Dong-gu, Daegu 701-310, Korea.
  • Suh PG; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan 689-798, Korea.
  • Choi JH; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan 689-798, Korea,. Electronic address: janghchoi@unist.ac.kr.
J Biol Chem ; 289(38): 26618-26629, 2014 Sep 19.
Article em En | MEDLINE | ID: mdl-25100724

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzoatos / PPAR gama / Diabetes Mellitus Experimental / Quinase 5 Dependente de Ciclina / Hipoglicemiantes / Indóis Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzoatos / PPAR gama / Diabetes Mellitus Experimental / Quinase 5 Dependente de Ciclina / Hipoglicemiantes / Indóis Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article