Synthesis, DNA-binding, and photocleavage properties of a serious of porphyrin-daunomycin hybrids.
Nucleosides Nucleotides Nucleic Acids
; 33(9): 597-614, 2014.
Article
em En
| MEDLINE
| ID: mdl-25105451
ABSTRACT
It is widely accepted that the pharmacological activities of anthracyclines antitumor agents express when the quinone-containing chromophore intercalates into base pairs of the duplex DNA. We have successfully synthesized and investigated the DNA-interactions of hybrids composed with quinone chromophore and cationic porphyrin. Herein, a clinic anticancer drug, daunomycin, is introduced to the porphyrin hybrids through different lengths of amide alkyl linkages, and their interactions and cleavage to DNA were studied compared with the previous porphyrin-quinone hybrids. Spectral results and the determined binding affinity constants (Kb) show that the attachment of daunomycin to porphyrin could improve the DNA-binding and photocleaving abilities. The porphyrin-daunomycin hybrids may find useful employment in investigating the ligand-DNA interaction.
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Base de dados:
MEDLINE
Assunto principal:
Porfirinas
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DNA
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Daunorrubicina
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Clivagem do DNA
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article