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Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
Longo, Francesco; Russo, Isabella; Shimshek, Derya R; Greggio, Elisa; Morari, Michele.
Afiliação
  • Longo F; Department of Medical Sciences, Section of Pharmacology, and National Institute of Neuroscience, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy.
  • Russo I; Department of Biology, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.
  • Shimshek DR; Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Greggio E; Department of Biology, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.
  • Morari M; Department of Medical Sciences, Section of Pharmacology, and National Institute of Neuroscience, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy. Electronic address: m.morari@unife.it.
Neurobiol Dis ; 71: 62-73, 2014 Nov.
Article em En | MEDLINE | ID: mdl-25107341
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Proteínas Serina-Treonina Quinases / Inibidores Enzimáticos / Hipercinese / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Proteínas Serina-Treonina Quinases / Inibidores Enzimáticos / Hipercinese / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article