Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness.
Epigenomics
; 6(3): 267-75, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-25111481
ABSTRACT
AIM:
DNA methylation is a fundamental biologic process of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantages. Thus, DNA methyltransferases (DNMTs) appear to be ideal targets for drug intervention. MATERIALS &METHODS:
To develop a new generation of DNMT inhibitor, we analyzed the ability of peptides to selectively inhibit certain DNMT1-incuding complexes.RESULTS:
Our study demonstrates that the disruption of DNMT1/CFP1-including complexes increases the efficiency of chemotherapeutic treatment on established tumors in mice.CONCLUSION:
Our data opens a promising and innovative alternative to the development of DNMT inhibitors.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Transativadores
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DNA (Citosina-5-)-Metiltransferases
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Inibidores Enzimáticos
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Glioma
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article