Phosphathiahelicenes: synthesis and uses in enantioselective gold catalysis.
Chemistry
; 20(39): 12373-6, 2014 Sep 22.
Article
em En
| MEDLINE
| ID: mdl-25113927
ABSTRACT
Enantiomerically pure thiahelicenes displaying a terminal phosphole unit and a stereogenic phosphorus center have been prepared by oxidative photocyclization of a diaryl-olefin precursor. Starting from one of these phosphathiahelicene oxides, the corresponding trivalent phosphine-Au(I) complex is obtained with complete diastereoselectivity. It affords a new, excellent precatalyst for the enantioselective cycloisomerization of N-tethered enynes (up to 96 % ee).
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MEDLINE
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En
Ano de publicação:
2014
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Article