Cross-immunity and age patterns of influenza A(H5N1) infection.
Epidemiol Infect
; 143(6): 1119-24, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25115493
ABSTRACT
The age distribution of influenza A(H5N1) cases reported during 2006-2013 varied substantially between countries. As well as underlying demographic profiles, it is possible that cross-immunity contributed to the age distribution of reported cases seasonal influenza A(H1N1) and avian influenza A(H5N1) share the same neuraminidase subtype, N1. Using a mechanistic model, we measured the extent to which population age distribution and heterosubtypic cross-immunity could explain the observed age patterns in Cambodia, China, Egypt, Indonesia and Vietnam. Our results support experimental evidence that prior infection with H1N1 confers partial cross-immunity to H5N1, and suggest that more than 50% of spillover events did not lead to reported cases of infection as a result. We also identified age groups that have additional risk factors for influenza A(H5N1) not captured by demography or infection history.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reações Cruzadas
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Influenza Humana
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Virus da Influenza A Subtipo H5N1
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article