Bidirectional cargo transport: moving beyond tug of war.
Nat Rev Mol Cell Biol
; 15(9): 615-28, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-25118718
Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein motors, which move in opposite directions along microtubules. This bidirectional cargo movement is frequently described as a 'tug of war' between oppositely directed molecular motors attached to the same cargo. However, although many experimental and modelling studies support the tug-of-war paradigm, numerous knockout and inhibition studies in various systems have found that inhibiting one motor leads to diminished motility in both directions, which is a 'paradox of co-dependence' that challenges the paradigm. In an effort to resolve this paradox, three classes of bidirectional transport models--microtubule tethering, mechanical activation and steric disinhibition--are proposed, and a general mathematical modelling framework for bidirectional cargo transport is put forward to guide future experiments.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cinesinas
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Dineínas
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Microtúbulos
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Modelos Biológicos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article