Women with osteoarthritis have elevated synovial fluid levels of insulin-like growth factor (IGF)-1 and IGF-binding protein-3.
J Immunoassay Immunochem
; 36(3): 284-94, 2015.
Article
em En
| MEDLINE
| ID: mdl-25120154
ABSTRACT
The present study explores the possible connection between synovial fluid concentrations of insulin like growth factor (IGF-1), IGF-binding protein (IGFBP-3), leptin, and C-reactive protein (CRP) in osteoarthritis (OA). Synovial fluid specimens were obtained from a total of thirty-four individuals with and without OA. Protein-normalized measurements of IGF-1, IGFBP-3, and leptin concentrations in synovial fluid showed significantly (P < 0.05) elevated levels in women with knee OA but not in men. This study provides initial evidence that protein normalized IGF-1 and IGFBP-3 and leptin levels increase in synovial fluid of women but not in men with OA versus those without OA.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
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Líquido Sinovial
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Fator de Crescimento Insulin-Like I
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Caracteres Sexuais
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Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article