Epidemiological characteristics and immune status of children with Respiratory Syncytial Virus.
J Med Virol
; 87(2): 323-9, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25123681
ABSTRACT
Respiratory Syncytial Virus (RSV) infections are the dominant cause of pneumonia in children. In order to determine the epidemiological characteristics and immune status of children with Respiratory Syncytial Virus, a prospective study was performed among patients with RSV infection. Comparisons between RSV pneumonia group and normal control group, RSV pneumonia group had lower IL-2 (median levels, pg/ml 3.8 vs. 5.1, P < 0.01), and higher IL-4 (median levels, pg/ml 3.2 vs. 2.4, P < 0.01), IL-10 (median levels, pg/ml 12.2 vs. 2.3, P < 0.01), and IFN-γ (median levels, pg/ml 13.4 vs. 4.6, P < 0.01). The level of IgE among pneumonia patients caused by RSV increased sharply (median levels, mg/L 48.1 vs. 8.8, P < 0.01). Another amazing finding is that after birth, the degree of IgE of the children infected by RSV increases gradually with age. This effect is at its peak in 0.6 years old. The IgE and eosinophil levels were higher when patients suffered from RSV pneumonia with wheeze (IgE median levels, IU/ml with wheeze 72.74 vs. without wheeze 11.5, P < 0.05; eosinophil median levels, ×10(9) /l with wheeze 0.21 vs. without wheeze 0.05, P < 0.05). The main morbidity crowd is the children under the age of 1 year old. The downregulation of IL2 and the upregulation of IL-4, IL-10, IFN-γ, and IgE happen after RSV infection.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
/
Vírus Sincicial Respiratório Humano
/
Infecções por Vírus Respiratório Sincicial
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article