Hippo pathway key to ploidy checkpoint.
Cell
; 158(4): 695-696, 2014 Aug 14.
Article
em En
| MEDLINE
| ID: mdl-25126776
Tetraploid cells generated by abnormal cell division are often arrested during the cell cycle or cleared by apoptosis. Evasion of these defense mechanisms leads to genomic instability and tumorigenesis. In this issue, Ganem et al. report that extra centrosome-induced activation of the Hippo pathway kinase LATS2 is a key mechanism of tetraploidy-induced cell-cycle arrest.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Proteínas Serina-Treonina Quinases
/
Citocinese
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article