Your browser doesn't support javascript.
loading
Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties.
Ilyinsky, Nikolay S; Shchyolkina, Anna K; Borisova, Olga F; Mamaeva, Olga K; Zvereva, Maria I; Azhibek, Dulat M; Livshits, Mikhail A; Mitkevich, Vladimir A; Balzarini, Jan; Sinkevich, Yuri B; Luzikov, Yuri N; Dezhenkova, Lybov G; Kolotova, Ekaterina S; Shtil, Alexander A; Shchekotikhin, Andrey E; Kaluzhny, Dmitry N.
Afiliação
  • Ilyinsky NS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, Moscow 119991, Russia; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology, 9 Institutskiy Per., Dolgoprudny 141700, Russia. Electronic address: ilinsky_nick@mail.ru.
  • Shchyolkina AK; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, Moscow 119991, Russia.
  • Borisova OF; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, Moscow 119991, Russia.
  • Mamaeva OK; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, Moscow 119991, Russia.
  • Zvereva MI; Department of Chemistry, Lomonosov Moscow State University, GSP-1, 1-3 Leninskie Gory, Moscow 119991, Russia.
  • Azhibek DM; Department of Chemistry, Lomonosov Moscow State University, GSP-1, 1-3 Leninskie Gory, Moscow 119991, Russia; Skolkovo Institute of Science and Technology, 100 Novaya Street, Skolkovo 143025, Russia.
  • Livshits MA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, Moscow 119991, Russia; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology, 9 Institutskiy Per., Dolgoprudny 141700, Russia.
  • Mitkevich VA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, Moscow 119991, Russia.
  • Balzarini J; Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
  • Sinkevich YB; Mendeleyev University of Chemical Technology, 9 Miusskaya Square, Moscow 125190, Russia.
  • Luzikov YN; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia.
  • Dezhenkova LG; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia.
  • Kolotova ES; Blokhin Cancer Center, 24 Kashirskoye Shosse, Moscow 115478, Russia; Moscow Engineering and Physics Institute, 31 Kashirskoye Shosse, Moscow 115409, Russia.
  • Shtil AA; Blokhin Cancer Center, 24 Kashirskoye Shosse, Moscow 115478, Russia; Moscow Engineering and Physics Institute, 31 Kashirskoye Shosse, Moscow 115409, Russia.
  • Shchekotikhin AE; Mendeleyev University of Chemical Technology, 9 Miusskaya Square, Moscow 125190, Russia; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia.
  • Kaluzhny DN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, Moscow 119991, Russia.
Eur J Med Chem ; 85: 605-14, 2014 Oct 06.
Article em En | MEDLINE | ID: mdl-25127152
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiofenos / Telomerase / Guanidina / Quadruplex G Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiofenos / Telomerase / Guanidina / Quadruplex G Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article