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The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML).
Elliot, Kathleen; Tooze, Janet A; Geller, Rachel; Powell, Bayard L; Pardee, Timothy S; Ritchie, Ellen; Kennedy, LeAnne; Callahan, Kathryn E; Klepin, Heidi D.
Afiliação
  • Elliot K; Section on Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: kelliot@wakehealth.edu.
  • Tooze JA; Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA; Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC, USA. Electronic address: jtooze@wakehealth.edu.
  • Geller R; Wake Forest Translational Science Institute, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: rgeller@wakehealth.edu.
  • Powell BL; Section on Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA; Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC, USA. Electronic address: bpowell@wakehealth.edu.
  • Pardee TS; Section on Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA; Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC, USA. Electronic address: tspardee@wakehealth.edu.
  • Ritchie E; Weill Cornell Medical College, New York, NY, USA. Electronic address: ritchie@med.cornell.edu.
  • Kennedy L; Section on Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: lakenned@wakehealth.edu.
  • Callahan KE; Department of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: kecallah@wakehealth.edu.
  • Klepin HD; Section on Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA; Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC, USA. Electronic address: hklepin@wakehealth.edu.
Leuk Res ; 38(10): 1184-90, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25127690
We retrospectively evaluated the prognostic significance of polypharmacy and inappropriate medication use among 150 patients >60 years of age receiving induction chemotherapy for acute myelogenous leukemia (AML). After adjustment for age and comorbidity, increased number of medications at diagnosis (≥ 4 versus ≤ 1) was associated with increased 30-day mortality (OR=9.98, 95% CI=1.18-84.13), lower odds of complete remission status (OR=0.20, 95% CI=0.06-0.65), and higher overall mortality (HR=2.13, 95% CI=1.15-3.92). Inappropriate medication use (classified according to Beers criteria) was not significantly associated with clinical outcomes. Polypharmacy warrants further study as a modifiable marker of vulnerability among older adults with AML.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Polimedicação / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Polimedicação / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article