Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
J Nat Prod
; 77(9): 2021-8, 2014 Sep 26.
Article
em En
| MEDLINE
| ID: mdl-25136754
ABSTRACT
Four new anthraquinone derivatives (1-4) and four new alterporriol-type anthranoid dimers (14-17), along with 17 analogues, were isolated from the solid rice fermentation of the fungus Stemphylium sp. 33231 obtained from the mangrove Bruguiera sexangula var. rhynchopetala collected from the South China Sea. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configurations of 1, 3, and 4 were determined by single-crystal X-ray diffraction of their derivatives (1a, 3b, and 4a). The absolute configurations of the chiral 17-19 were determined by comparing their CD spectra with 21. The inhibitory activities of most of the compounds against seven terrestrial pathogenic bacteria and two cancer cell lines were evaluated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Antraquinonas
/
Rhizophoraceae
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article