Functionalised nanoparticles complexed with antibiotic efficiently kill MRSA and other bacteria.
Chem Commun (Camb)
; 50(81): 12030-3, 2014 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-25136934
ABSTRACT
Antibiotic-resistant bacterial infections are a vexing global health problem and have rendered ineffective many previously-used antibiotics. Here we demonstrate that antibiotic-linkage to surface-functionalized silica nanoparticles (sNP) significantly enhances their effectiveness against Escherichia coli, and Staphylococcus aureus, and even methicillin-resistant S. aureus (MRSA) strains that are resistant to most antibiotics. The commonly-used antibiotic penicillin-G (PenG) was complexed to dye-labeled sNPs (15 nm diameter) containing carboxyl groups located as either surface-functional groups, or on polymer-chains extending from surfaces. Both sNPs configurations efficiently killed bacteria, including MRSA strains. This suggests that activities of currently-ineffective antibiotics can be restored by nanoparticle-complexation and used to avert certain forms of antibiotic-resistance.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nanopartículas
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Staphylococcus aureus Resistente à Meticilina
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Antibacterianos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article