Anti-Mullerian hormone levels in American girls by age and race/ethnicity.

ABSTRACT

BACKGROUND: Anti-Mullerian Hormone (AMH), a proposed indicator of ovarian follicle reserve in adults, has not been characterized in pediatric and adolescent females by race and/or ethnicity. OBJECTIVES: To describe AMH levels in healthy American girls and determine the influence of age and race/ethnicity on AMH. SUBJECTS: SUBJECTS aged 10-21 years were recruited from primary care settings and emergency departments. Race/ethnicity was characterized as White, Black or Hispanic. METHODS: Serum for AMH levels (ng/mL) was measured using an enzyme-linked immunosorbent assay. RESULTS: Thirty-one White, 60 Black and 24 Hispanic subjects were recruited. Mean AMH levels were 3.19 ng/mL (22.8 pmol/L) (SD 2.12) for Whites, 3.25 ng/mL (23.2 pmol/L) (SD 2.23) for Blacks and 2.97 ng/mL (21.2 pmol/L) (SD 1.75) for Hispanics. ANCOVA showed no difference in AMH levels among race/ethnicities, controlling for age (p=0.91). Age was significantly associated with AMH (p<0.001, R²=0.12). CONCLUSION: AMH levels do not vary by race/ethnicity, and AMH levels increase with age.