Association of Neurotensin receptor 1 gene polymorphisms with processing speed in healthy Chinese-Han subjects.
J Mol Neurosci
; 54(4): 787-9, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25159184
ABSTRACT
Neurotensin modulates dopamine and serotonin transmission in the brain. The study investigated whether genetic polymorphisms in the Neurotensin receptor 1 gene were associated with performance on processing speed and executive function. A total of 129 healthy Chinese-Han volunteers were recruited. Genotyping for three SNPs, including rs6090453, rs6011914, and rs2427422, was analyzed by using a PCR and a restriction fragment length polymorphism analysis. Performances of processing speed and executive function were assessed by using Trail Making Test-A (TMT-A), Wisconsin Card Sorting Test, and Stroop Color-Word Test. We found significant differences in the outcomes of TMT-A score among rs6090453C/G (F(2,126)=4.405, P=0.014) and rs2427422A/G (F(2,126)=7.498, P=0.001) genotypes. Neurotensin receptor 1 SNP polymorphisms were significantly associated with the variance in processing speed performance in a sample of Chinese college students.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aprendizagem Verbal
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Receptores de Neurotensina
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Polimorfismo de Nucleotídeo Único
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Função Executiva
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article