Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.

Emoto, Chie; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Cox, Shareen; Schniedewind, Björn; Christians, Uwe; Widemann, Brigitte C; Fisher, Michael J; Weiss, Brian; Perentesis, John; Vinks, Alexander A

Emoto, Chie; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Cox, Shareen; Schniedewind, Björn; Christians, Uwe; Widemann, Brigitte C; Fisher, Michael J; Weiss, Brian; Perentesis, John; Vinks, Alexander A.

Afiliação

Emoto C; *Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, College of Medicine, University of Cincinnati, OH; iC42 Integrated Solutions in Clinical Research and Development, University of Colorado, Aurora; §Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD; ¶Division of Oncology, The Children's Hospital of Philadelphia; âDepartment of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia; **Divis

Ther Drug Monit ; 37(3): 395-9, 2015 Jun.

Article em En | MEDLINE | ID: mdl-25162215

Assuntos

Envelhecimento/metabolismo; Imunossupressores/metabolismo; Imunossupressores/farmacocinética; Neurofibromatose 1/metabolismo; Sirolimo/metabolismo; Sirolimo/farmacocinética; Adolescente; Adulto; Envelhecimento/sangue; Criança; Pré-Escolar; Citocromo P-450 CYP3A/metabolismo; Feminino; Humanos; Imunossupressores/sangue; Masculino; Pessoa de Meia-Idade; Neurofibromatose 1/sangue; Sirolimo/análogos & derivados; Sirolimo/sangue; Adulto Jovem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Neurofibromatose 1 / Sirolimo / Imunossupressores Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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