Balanced UTE-SSFP for 19F MR imaging of complex spectra.
Magn Reson Med
; 74(2): 537-43, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25163853
ABSTRACT
PURPOSE:
A novel technique for highly sensitive detection of multiresonant fluorine imaging agents was designed and tested with the use of dual-frequency 19F/1H ultrashort echo times (UTE) sampled with a balanced steady-state free precession (SSFP) pulse sequence and three-dimensional (3D) radial readout.METHODS:
Feasibility of 3D radial balanced UTE-SSFP imaging was demonstrated for a phantom comprising liquid perfluorooctyl bromide (PFOB). Sensitivity of the pulse sequence was measured and compared with other sequences imaging the PFOB (CF2 )6 line group including UTE radial gradient-echo (GRE) at α = 30°, as well as Cartesian GRE, balanced SSFP, and fast spin-echo (FSE). The PFOB CF3 peak was also sampled with FSE.RESULTS:
The proposed balanced UTE-SSFP technique exhibited a relative detection sensitivity of 51 µmolPFOB(-1) min(-1/2) (α = 30°), at least twice that of other sequence types with either 3D radial (UTE GRE 20 µmolPFOB(-1) min(-1/2) ) or Cartesian k-space filling (GRE 12 µmolPFOB(-1) min(-1/2) ; FSE 16 µmolPFOB(-1) min(-1/2) ; balanced SSFP 23 µmolPFOB(-1) min(-1/2) ). In vivo imaging of angiogenesis-targeted PFOB nanoparticles was demonstrated in a rabbit model of cancer on a clinical 3 Tesla scanner.CONCLUSION:
A new dual 19F/1H balanced UTE-SSFP sequence manifests high SNR, with detection sensitivity more than two-fold better than traditional techniques, and alleviates imaging problems caused by dephasing in complex spectra.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Algoritmos
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Processamento de Sinais Assistido por Computador
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Interpretação de Imagem Assistida por Computador
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Imagem por Ressonância Magnética de Flúor-19
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Neoplasias Experimentais
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article