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Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication.
Carneiro, Miguel; Rubin, Carl-Johan; Di Palma, Federica; Albert, Frank W; Alföldi, Jessica; Martinez Barrio, Alvaro; Pielberg, Gerli; Rafati, Nima; Sayyab, Shumaila; Turner-Maier, Jason; Younis, Shady; Afonso, Sandra; Aken, Bronwen; Alves, Joel M; Barrell, Daniel; Bolet, Gerard; Boucher, Samuel; Burbano, Hernán A; Campos, Rita; Chang, Jean L; Duranthon, Veronique; Fontanesi, Luca; Garreau, Hervé; Heiman, David; Johnson, Jeremy; Mage, Rose G; Peng, Ze; Queney, Guillaume; Rogel-Gaillard, Claire; Ruffier, Magali; Searle, Steve; Villafuerte, Rafael; Xiong, Anqi; Young, Sarah; Forsberg-Nilsson, Karin; Good, Jeffrey M; Lander, Eric S; Ferrand, Nuno; Lindblad-Toh, Kerstin; Andersson, Leif.
Afiliação
  • Carneiro M; CIBIO/InBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Universidade do Porto, 4485-661, Vairão, Portugal.
  • Rubin CJ; Science of Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
  • Di Palma F; Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.
  • Albert FW; Vertebrate and Health Genomics, The Genome Analysis Center, Norwich, UK.
  • Alföldi J; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Martinez Barrio A; Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.
  • Pielberg G; Science of Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
  • Rafati N; Science of Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
  • Sayyab S; Science of Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
  • Turner-Maier J; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Younis S; Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.
  • Afonso S; Science of Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
  • Aken B; Department of Animal Production, Ain Shams University, Shoubra El-Kheima, Cairo, Egypt.
  • Alves JM; CIBIO/InBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Universidade do Porto, 4485-661, Vairão, Portugal.
  • Barrell D; Wellcome Trust Sanger Institute, Hinxton, UK.
  • Bolet G; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Boucher S; CIBIO/InBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Universidade do Porto, 4485-661, Vairão, Portugal.
  • Burbano HA; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK.
  • Campos R; Wellcome Trust Sanger Institute, Hinxton, UK.
  • Chang JL; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Duranthon V; INRA, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, F-31326 Castanet-Tolosan, France.
  • Fontanesi L; Labovet Conseil, Les Herbiers Cedex, France.
  • Garreau H; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Heiman D; CIBIO/InBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Universidade do Porto, 4485-661, Vairão, Portugal.
  • Johnson J; Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.
  • Mage RG; INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France.
  • Peng Z; Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, 40127 Bologna Italy.
  • Queney G; INRA, UMR1388 Génétique, Physiologie et Systèmes d'Elevage, F-31326 Castanet-Tolosan, France.
  • Rogel-Gaillard C; Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.
  • Ruffier M; Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.
  • Searle S; Laboratory of Immunology, NIAID, NIH, Bethesda, MD, 20892, USA.
  • Villafuerte R; DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, 2800 Mitchell Drive, Walnut Creek, CA 94598.
  • Xiong A; ANTAGENE, Animal Genomics Laboratory, Lyon, France.
  • Young S; INRA, UMR1313 Génétique Animale et Biologie Intégrative, F- 78350, Jouy-en-Josas, France.
  • Forsberg-Nilsson K; Wellcome Trust Sanger Institute, Hinxton, UK.
  • Good JM; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Lander ES; Wellcome Trust Sanger Institute, Hinxton, UK.
  • Ferrand N; Instituto de Estudios Sociales Avanzados, (IESA-CSIC) Campo Santo de los Mártires 7, Córdoba Spain.
  • Lindblad-Toh K; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Andersson L; Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.
Science ; 345(6200): 1074-1079, 2014 Aug 29.
Article em En | MEDLINE | ID: mdl-25170157
The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Coelhos / Animais Domésticos / Animais Selvagens Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Coelhos / Animais Domésticos / Animais Selvagens Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article