Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis.
Eur J Med Chem
; 86: 270-8, 2014 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-25171781
ABSTRACT
The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy has been developed for the rapid and milder access to this class of compounds some of which showed interesting pharmacological properties when tested in vitro and in zebrafish embryos.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Paládio
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Pirróis
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Quinoxalinas
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Tiofenos
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Apoptose
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Inibidores da Fosfodiesterase 4
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article