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Effect of anti-PMSG on distribution of estrogen receptor alpha and progesterone receptor in mouse ovary, oviduct and uterus.
Lin, Zi Li; Ni, He Min; Liu, Yun Hai; Sheng, Xi Hui; Cui, Xiang Shun; Kim, Nam Hyung; Guo, Yong.
Afiliação
  • Lin ZL; Department of Animal Sciences,Chungbuk National University,Cheongju,Korea.
  • Ni HM; College of Animal Science and Technology,Beijing University of Agriculture,Beijing,China.
  • Liu YH; College of Animal Science and Technology,Beijing University of Agriculture,Beijing,China.
  • Sheng XH; College of Animal Science and Technology,Beijing University of Agriculture,Beijing,China.
  • Cui XS; Department of Animal Sciences,Chungbuk National University,Cheongju,Korea.
  • Kim NH; Department of Animal Sciences,Chungbuk National University,Cheongju,Korea.
  • Guo Y; College of Animal Science and Technology,Beijing University of Agriculture,Beijing,China.
Zygote ; 23(5): 695-703, 2015 Oct.
Article em En | MEDLINE | ID: mdl-25181308
It is well established that estrogen and progesterone are critical endogenous hormones that are essential for implantation and pregnancy in females. However, the distribution of estrogen receptor α (ERα) and progesterone receptor (PR) in female reproductive tracts is elusive. Herein, we report that after serial treatments with pregnant mare's serum gonadotrophin (PMSG) with or without anti-PMSG (AP), mice could regulate the distribution of ERα and PR in the murine ovary, oviduct and uterus and the level of estradiol in serum. ERα and PR regulation by PMSG and anti-PMSG was estrous cycle-dependent and critical for promoting the embryo-implantation period. Furthermore, our results suggested that AP-42 h treatment is more effective than the other treatments. In contrast, other treatment groups also affected the distribution of ERα and PR in mouse reproductive tracts. Thus, we found that anti-PMSG has the potential to restore the distribution of ERα and PR, which could effectively reduce the negative impact of residual estrogen caused by the normal superovulation effect of PMSG in mice.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ovário / Oviductos / Útero / Receptores de Progesterona / Gonadotropinas Equinas / Receptor alfa de Estrogênio / Soros Imunes Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ovário / Oviductos / Útero / Receptores de Progesterona / Gonadotropinas Equinas / Receptor alfa de Estrogênio / Soros Imunes Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2015 Tipo de documento: Article