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Inhibition of the MDM2 E3 Ligase induces apoptosis and autophagy in wild-type and mutant p53 models of multiple myeloma, and acts synergistically with ABT-737.
Gu, Dongmin; Wang, Shuhong; Kuiatse, Isere; Wang, Hua; He, Jin; Dai, Yun; Jones, Richard J; Bjorklund, Chad C; Yang, Jing; Grant, Steven; Orlowski, Robert Z.
Afiliação
  • Gu D; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
  • Wang S; Department of Hematology, Chinese PLA General Hospital, Beijing, China.
  • Kuiatse I; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
  • Wang H; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
  • He J; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
  • Dai Y; Department of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States of America.
  • Jones RJ; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
  • Bjorklund CC; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
  • Yang J; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
  • Grant S; Department of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States of America.
  • Orlowski RZ; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
PLoS One ; 9(9): e103015, 2014.
Article em En | MEDLINE | ID: mdl-25181509
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Sulfonamidas / Compostos de Bifenilo / Proteína Supressora de Tumor p53 / Apoptose / Proteínas Proto-Oncogênicas c-mdm2 / Mieloma Múltiplo / Mutação / Nitrofenóis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Sulfonamidas / Compostos de Bifenilo / Proteína Supressora de Tumor p53 / Apoptose / Proteínas Proto-Oncogênicas c-mdm2 / Mieloma Múltiplo / Mutação / Nitrofenóis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article