Antibacterial synergy of glycerol monolaurate and aminoglycosides in Staphylococcus aureus biofilms.
Antimicrob Agents Chemother
; 58(11): 6970-3, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25182634
ABSTRACT
Glycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At â¼0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistant Staphylococcus aureus biofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acted synergistically with gentamicin and streptomycin, but not ampicillin or vancomycin, to eliminate detectable viable biofilm bacteria. Images of GML-treated biofilms suggested that GML may facilitate antibiotic interaction with matrix-embedded bacteria.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Biofilmes
/
Monoglicerídeos
/
Aminoglicosídeos
/
Lauratos
/
Antibacterianos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article