Synthesis of (±)-terpendole E.
Biosci Biotechnol Biochem
; 79(1): 11-5, 2015.
Article
em En
| MEDLINE
| ID: mdl-25184606
ABSTRACT
The first synthesis of the racemate of terpendole E, a specific inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves diastereoselective installation of its C3 quaternary stereocenter via a cyclopropyl ketone intermediate and Pd-mediated two-step construction of the indole ring moiety as the key transformations.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diterpenos
/
Inibidores Enzimáticos
/
Indóis
/
Cetonas
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article