5-Caffeoylquinic acid decreases diet-induced obesity in rats by modulating PPARα and LXRα transcription.
J Sci Food Agric
; 95(9): 1903-10, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25186103
ABSTRACT
BACKGROUND:
Chlorogenic acids (CGAs) are widely distributed in plant material, including foods and beverages. 5-Caffeoylquinic acid (5-CQA) is the most studied CGA, but the mechanism of its hypolipidaemic effect remains unclear. This study aimed to determine the effect of 5-CQA on lipid metabolism in the liver of Sprague-Dawley rats fed a high-fat diet (HFD).RESULTS:
5-CQA suppressed HFD-induced increases in body weight and visceral fat-pad weight, serum lipid levels, and serum and hepatic free fatty acids in a dose-dependent manner. Real-time polymerase chain reaction revealed that 5-CQA altered the mRNA expression of the transcription factors peroxisome proliferator-activated receptor α (PPARα) and liver X receptor α (LXRα) and target genes involved in hepatic fatty acid uptake, ß-oxidation, fatty acid synthesis, and cholesterol synthesis. Moreover, hepatic tissue sections from HFD-fed rats showed many empty vacuoles, suggesting that liver cells were filled with more fat droplets. However, 5-CQA significantly ameliorated this effect.CONCLUSION:
5-CQA may improve lipid metabolism disorders by altering the expression of PPARα and LXRα, which are involved in multiple intracellular signalling pathways.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Quínico
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Ácido Clorogênico
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Fármacos Antiobesidade
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Suplementos Nutricionais
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PPAR alfa
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Receptores Nucleares Órfãos
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Fígado
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Obesidade
Tipo de estudo:
Etiology_studies
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article