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Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists.
Hasui, Tomoaki; Ohyabu, Norio; Ohra, Taiichi; Fuji, Koji; Sugimoto, Takahiro; Fujimoto, Jun; Asano, Kouhei; Oosawa, Masato; Shiotani, Sachiko; Nishigaki, Nobuhiro; Kusumoto, Keiji; Matsui, Hideki; Mizukami, Atsushi; Habuka, Noriyuki; Sogabe, Satoshi; Endo, Satoshi; Ono, Midori; Siedem, Christopher S; Tang, Tony P; Gauthier, Cassandra; De Meese, Lisa A; Boyd, Steven A; Fukumoto, Shoji.
Afiliação
  • Hasui T; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: tomoaki.hasui@takeda.com.
  • Ohyabu N; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Ohra T; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Fuji K; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Sugimoto T; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Fujimoto J; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Asano K; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Oosawa M; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Shiotani S; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Nishigaki N; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Kusumoto K; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Matsui H; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Mizukami A; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Habuka N; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Sogabe S; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Endo S; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Ono M; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Siedem CS; Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, United States.
  • Tang TP; Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, United States.
  • Gauthier C; Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, United States.
  • De Meese LA; Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, United States.
  • Boyd SA; Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, United States.
  • Fukumoto S; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Bioorg Med Chem ; 22(19): 5428-45, 2014 Oct 01.
Article em En | MEDLINE | ID: mdl-25187277
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxazinas / Pirazóis / Receptores de Mineralocorticoides / Antagonistas de Receptores de Mineralocorticoides / Descoberta de Drogas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxazinas / Pirazóis / Receptores de Mineralocorticoides / Antagonistas de Receptores de Mineralocorticoides / Descoberta de Drogas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article