Perioperative blood transfusion and radical cystectomy: does timing of transfusion affect bladder cancer mortality?
Eur Urol
; 66(6): 1139-47, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25194909
ABSTRACT
BACKGROUND:
While perioperative blood transfusion (BT) has been associated with adverse outcomes in multiple malignancies, the importance of BT timing has not been established.OBJECTIVE:
The objective of this study was to evaluate whether intraoperative BT is associated with worse cancer outcomes in bladder cancer patients treated with radical cystectomy (RC). DESIGN, SETTING, ANDPARTICIPANTS:
Outcomes from two independent cohorts of consecutive patients with bladder cancer treated with RC were analyzed. OUTCOME MEASUREMENTS AND STATISTICALANALYSIS:
Recurrence-free survival, cancer-specific survival (CSS), and overall survival were estimated and multivariate analyses were performed to evaluate the association of BT timing with cancer outcomes. RESULTS ANDLIMITATIONS:
In the primary cohort of 360 patients, 241 (67%) received perioperative BT, including 162 intraoperatively and 79 postoperatively. Five-year CSS was 44% among patients who received an intraoperative BT versus 64% for patients who received postoperative BT (p=0.0005). After multivariate analysis, intraoperative BT was associated with an increased risk of cancer mortality (hazard ratio [HR] 1.93; p=0.02), while receipt of postoperative BT was not (p=0.60). In the validation cohort of 1770 patients, 1100 (62%) received perioperative BT with a median postoperative follow-up of 11 yr (interquartile range 8.0-15.7). Five-year RFS (p<0.001) and CSS (p<0.001) were significantly worse among patients who received an intraoperative BT. Intraoperative BT was independently associated with recurrence (HR 1.45; p=0.001), cancer-specific mortality (HR 1.55; p=0.0001), and all-cause mortality (HR 1.40; p<0.0001). Postoperative BT was not associated with risk of disease recurrence or cancer death.CONCLUSIONS:
Intraoperative BT is associated with increased risk of bladder cancer recurrence and mortality. PATIENTSUMMARY:
In this study, the effects of blood transfusion on bladder cancer surgery outcomes were evaluated. Intraoperative blood transfusion, but not postoperative transfusion, was associated with higher rates of recurrence and cancer-specific mortality.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cuidados Pós-Operatórios
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Neoplasias da Bexiga Urinária
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Transfusão de Sangue
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Carcinoma
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Cuidados Intraoperatórios
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Recidiva Local de Neoplasia
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article