Apo E gene polymorphism affects development of type 2 diabetic nephropathy in Asian populations, especially in East Asians: an updated meta-analysis.
Med Sci Monit
; 20: 1596-603, 2014 Sep 08.
Article
em En
| MEDLINE
| ID: mdl-25196797
ABSTRACT
BACKGROUND:
Many studies have determined the correlation between the Apolipoprotein E (APO E) gene polymorphisms and diabetic nephropathy, but their results are inconclusive. MATERIAL/METHODS:
With the aim to confirm this correlation, we performed a meta-analysis of 16 studies. The dichotomous data are presented as the odds ratio (OR) with a 95% conï¬dence interval (CI).RESULTS:
The results of our study indicate that APO ε2 allele among the pooled Asian populations were more likely to show high risk of DN development (2 allele vs. ε3 allele pooled OR =1.629, 95% CI=1.010-2.628, P=0.045). For further analysis, the APO e2 allele was associated with progress of DN in the group with duration >10 years, but not in the group with duration <10 years (ε2 allele vs. ε3 allele pooled OR=1.920, 95% CI=1.338-2.754, P<0.001). The APO e2 polymorphism increased the susceptibility to DN in Asian population compared with healthy people (ε2 allele vs. ε3 allele pooled OR=1.629, 95% CI=1.010-2.628, P=0.045).CONCLUSIONS:
Development of DN is associated with APO E polymorphisms in Asian populations, especially in East Asians.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
/
Polimorfismo Genético
/
Predisposição Genética para Doença
/
Povo Asiático
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Diabetes Mellitus Tipo 2
/
Nefropatias Diabéticas
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article